
NSC 19630
CAS No. 72835-26-8
NSC 19630 ( MIRA-1 )
产品货号. M15787 CAS No. 72835-26-8
NSC 19630 (MIRA-1) 是一种有效的选择性维尔纳综合征解旋酶(WRN 解旋酶),IC50 为 20 uM。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥275 | 有现货 |
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5MG | ¥446 | 有现货 |
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10MG | ¥786 | 有现货 |
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25MG | ¥1596 | 有现货 |
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50MG | ¥2406 | 有现货 |
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100MG | ¥3637 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称NSC 19630
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述NSC 19630 (MIRA-1) 是一种有效的选择性维尔纳综合征解旋酶(WRN 解旋酶),IC50 为 20 uM。
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产品描述NSC 19630 (MIRA-1) is a potent, selective Werner syndrome helicase (WRN helicase) with IC50 of 20 uM; shows selecitvity over human RecQ helicases (RECQ1 and BLM), Fanconi anemia group J (FANCJ) helicases and three Escherichia coli helicases (RecQ, UvrD, and DnaB); dramatically impaires growth and proliferation, induces apoptosis in a WRN-dependent manner, and resultes in elevated γ-H2AX and PCNA foci in human cells; delays S-phase progression and induces DNA damage; a mutant p53 reactivator that induces mutant p53-dependent cell death in different human tumor cells carrying tetracycline-regulated mutant p53.
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体外实验Cell Proliferation Assay Cell Line:Saos-2-His273, H1299-His175, SKOV-His175 and SKOV-His273 Concentration:25 μM Incubation Time:48 hours Result:Inhibited cell growth in a mutant p53-dependent manner, with survival rate of 18.5~39% in no doxycycline and 71.5~87.5% in doxycycline.Apoptosis Analysis Cell Line:Saos-2 and Saos-2-His273 cells Concentration:10 μM Incubation Time:48 hours Result:Caused a substantial increase in the fraction of cells with a sub-G1 DNA content in the presence of mutant p53.
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体内实验——
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同义词MIRA-1
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通路Cell Cycle/DNA Damage
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靶点DNA Repair Protein
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受体DNA Repair Protein
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研究领域——
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适应症——
化学信息
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CAS Number72835-26-8
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分子量183.2
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分子式C8H9NO4
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (545.97 mM)
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SMILESO=C(C=C1)N(COC(CC)=O)C1=O
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化学全称1-[(1-oxopropoxy)methyl]-1H-pyrrole-2,5-dione
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Aggarwal M, et al. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1525-30.
2. Saha MN, et al. Br J Cancer. 2014 Apr 29;110(9):2224-31.
3. Bykov VJ, et al. J Biol Chem. 2005 Aug 26;280(34):30384-91.
产品手册




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